Sunesis Pharmaceuticals to Present Non-Clinical Data at the Annual Meeting of the American Association for Cancer Research
SOUTH SAN FRANCISCO, Calif., April 9, 2008, 2008 /PRNewswire-FirstCall via COMTEX News Network/ -- Sunesis Pharmaceuticals, Inc. (Nasdaq: SNSS) today announced that the company will present data on each of its clinical-stage anticancer compounds at the upcoming Annual Meeting of the American Association for Cancer Research (AACR) being held April 12-16 in San Diego, CA. Sunesis has built a portfolio of product candidates in oncology focused on novel pathways and targets, including inhibition of the cell cycle and survival signaling.
Data from non-clinical studies of SNS-595, SNS-032 and SNS-314 will be presented in five posters and one oral presentation during the AACR Meeting. New insights on the mechanism of action and anticancer activity of SNS-595, Sunesis' lead compound, will be featured on Monday, April 14, 2008. SNS-595 is a novel naphthyridine analog structurally related to quinolones, a class of compounds which has not been used previously for the treatment of cancer. SNS-595 both selectively intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent DNA damage, irreversible G2 arrest and rapid apoptosis. A Phase 2 single agent clinical trial of SNS-595 in ovarian cancer and a Phase 1b combination clinical trial with cytarabine in relapsed/refractory acute myeloid leukemia are both ongoing.
SNS-595 Poster Presentations Monday, April 14, 2008 -- SNS-595 is a potent anti-tumor agent that has a dual mechanism of action: DNA intercalation and site-selective topoisomerase II poisoning Session: Stress Responses Abstract #1860 8:00 a.m. - 12:00 p.m. Exhibit Hall B-F, San Diego Convention Center -- Sensitivity to SNS-595 is related to activation of double strand DNA break repair pathways including homologous recombination Session: Stress Responses Abstract #1859 8:00 a.m. - 12:00 p.m. Exhibit Hall B-F, San Diego Convention Center -- Ex vivo activity of SNS-595 against biopsies of acute myeloid leukemia, triple negative breast and ovarian cancers supports ongoing and potential clinical indications Session: Novel Drug Targets, Agents and Mechanisms Abstract #2830 1:00 p.m. - 5:00 p.m. Exhibit Hall B-F, San Diego Convention Center
Suzanne Trudel, MSc, M.D., Assistant Professor, Princess Margaret Hospital, University Health Network, will provide an oral presentation on SNS-032's preclinical activity in multiple myeloma as part of a minisymposium on Tuesday, April 15, 2008. In addition, translational research data detailing the relationship between SNS-032's mechanism and its activity in certain types of cancer will be presented in a poster. SNS-032, a potent and selective inhibitor of cyclin-dependent kinases 2, 7 and 9, is being evaluated in a Phase 1 clinical trial in patients with relapsed/refractory chronic lymphocytic leukemia or multiple myeloma.
SNS-032 Oral Presentation Tuesday, April 15, 2008 -- SNS-032, a potent and selective CDK2, 7 and 9 inhibitor, demonstrates preclinical activity in human multiple myeloma Minisymposium: Novel Genomic Approaches, Drugs, Targets, and Strategies Abstract #4972 4:55 p.m. to 5:10 p.m. Room 30A-C, San Diego Convention Center SNS-032 Poster Presentation Sunday, April 13, 2008 -- SNS-032, a novel inhibitor of cyclin-dependent kinases 2, 7, and 9, blocks transcription of cyclin D1 and Mcl-1, causing cell death in mantle cell lymphoma cell lines Session: Histone Deacetylase Inhibitors and Cell Cycle Inhibitors Abstract #756 8:00 a.m. - 12:00 p.m. Exhibit Hall B-F, San Diego Convention Center
Preclinical data providing new details on SNS-314's anti-tumor activity will be presented Wednesday, April 16, 2008. SNS-314, a potent and selective pan-Aurora kinase inhibitor, is being studied in a Phase 1 dose-escalating clinical trial in patients with advanced solid tumors.
SNS-314 Poster Presentation Wednesday, April 16, 2008 -- SNS-314, a potent inhibitor of Aurora kinases, has preclinical anti-activity and induces apoptosis Session: Heat Shock Protein Inhibitors, Aurora Kinase and other Mitotic Inhibitors Abstract #5648 8:00 a.m. - 12:00 p.m. Exhibit Hall B-F, San Diego Convention Center
About Sunesis Pharmaceuticals
Sunesis is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of novel small molecule therapeutics for oncology and other serious diseases. Sunesis has built a broad product candidate portfolio through internal discovery and in-licensing of novel cancer therapeutics. Sunesis is advancing its product candidates through in-house research and development efforts and strategic collaborations with leading pharmaceutical and biopharmaceutical companies. For additional information on Sunesis Pharmaceuticals, please visit http://www.sunesis.com.
SUNESIS and the logo are trademarks of Sunesis Pharmaceuticals, Inc.
SOURCE Sunesis Pharmaceuticals, Inc.
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